Nakamura 29_6
نویسندگان
چکیده
SU6668 is an antiangiogenic agent that acts as a tyrosine kinase inhibitor for the vascular endothelial growth factor (VEGF) receptor. We treated xenografted A-431, a human squamous cell carcinoma cell line, with SU6668 to investigate the efficacy of tumor dormant therapy using angiogenesis inhibitors for patients with squamous cell carcinoma. A-431 cells were transplanted into severe combined immunodeficient (SCID) mice. The treatment group was given SU6668 at a dose of 200 mg/kg orally twice a day for 3 weeks; the control group was given only the vehicle in the same manner and intervals. SU6668 suppressed tumor growth of A-431 cells in the xenograft model. Furthermore, tumor volume and the number of vessels were significantly reduced in the treatment group compared with those of the control. No significant differences in body weight were found between the treatment and control groups, and no toxic reactions occurred during the experiment. We concluded that this agent was safe, efficient and potentially useful for the treatment of patients with squamous cell carcinoma.
منابع مشابه
Polymorphisms and haplotypes of the CD209L gene and their association with the clinical courses of HIV-positive Japanese patients.
Noriko Kobayashi, Hitomi Taguchi-Nakamura, Mieko Goto, Tetsuya Nakamura, Koichiro Nakamura, Wataru Sugiura, Aikichi Iwamoto and Yoshihiro Kitamura* Division of Infectious Diseases, Advanced Clinical Research Center and Division of Infectious Diseases and Applied Immunology, Institute of Medical Science, University of Tokyo, Shirokanedai 4-6-1, Minato-ku, Tokyo 108-8639, Department Dermatology, ...
متن کاملInflight Calibration of Asteroid Multiband Imaging Camera Onboard
HAYABUSA: PRELIMINARY RESULTS. R. Nakamura , M. Ishiguro, A. M. Nakamura, N. Hirata, J. Terazono, A. Yamamoto, M. Abe, T. Hashimoto and J. Saito, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, 2-1-1 Sengen, Tsukuba, Ibaraki, 305-8505, Japan ([email protected]) , Univ. of Hawaii, Kobe Univ., Remote sensing technology center of JAPAN, Nishimatsu constr...
متن کاملCrater Counting on Asteroid 25143
1 , R. Nakamura 2 , M. Ishiguro, J. Saito, T. Hashimoto, T. Kubota, A. M. Nakamura, N. Hirata, K. Hiraoka, H. Demura, T. Michikami 6 , 1 Institute of Space and Astronautical Sciences, Japan Aerospace Exploration Agency, 3-1-1 Yoshinodai, Sagamihara, Kanagawa, 229-8510, Japan ([email protected]), 2 National Institute of Advanced Science and Technology, 3 Seoul University, 4 Kobe Un...
متن کامل